The possibility of 4-1 or 5-0 breaks don’t really affect the line you should adopt.
So concentrating on a 3-2 trump break it is a case of finding the Jack and the King.
In simple terms there are 4 positional possibilities, all of which are equally likely
Kx(x) opposite Jx(x)
Jx(x) opposite Kx(x)
KJ(x) opposite xx(x)
xx(x) opposite KJ(x)
There are two equally good lines
1. Lead the Queen and run it if not covered. Then lead the 2 and finesse the 10.
This only loses 2 tricks when East holds both Jack and King (25% of the time)
2. Lead the 5 and finesse the 9. If this loses to the Jack, lead the Q and run it.
This only loses 2 tricks when West holds the Jack and East holds the King (25% of the time)
Mathematically both these lines are good
1. Has the merit of simplicity.
2. Has a slight psychological advantage in that East will sometimes rise with the King when holding Kx thus avoiding the inevitable 2 losers had East instead played low.
Playing the Ace and then low towards hand will often leave you to guess whether to play West for the Jack or King. This is not good for your nerves and mathematically slightly inferior.